Deadpool & Wolverine is shaping up to be the MCU’s biggest crossover event since Avengers: Endgame, with plenty of cameos throughout. Deadpool had his live-action debut in X-Men Origins: Wolverine in 2009, but it wasn’t until 2016 that the character was fully realized. On both occasions, the actor who played the role was Ryan Reynolds, a superfan of the Merc with the Mouth, and Reynolds was even referenced in a 2004 comic by Deadpool to describe the character’s appearance.

However, 2024s Deadpool & Wolverine will mark the first time Reynolds and Deadpool officially join the MCU. Up to this point, the character was only seen in the Fox universe, but with Disney acquiring Fox in 2019, the time has finally come for Deadpool and the Fox X-Men universe to come into the MCU family. And in order to mark the momentous occasion, Deadpool & Wolverine has cast many popular actors who have appeared in Marvel movies outside the MCU.

Sabertooth

Last Seen: X-Men (2000)

Tyler Mane was cast as Sabertooth for the premiere film in the Fox X-Men trilogy in 2000. The character was portrayed as wild and animalistic, even more so than his rival, Wolverine. While the character returned in 2009 with X-Men Origins: Wolverine, the actor was replaced with Liev Schreiber, and his origin was altered. Now, more than two decades later, the original Sabertooth is set to lock claws with his old enemy in Deadpool & Wolverine.

Elektra

Last Seen: Elektra (2005)

In 2003, Matt Murdock made his big screen debut when Ben Affleck starred as the Devil of Hell’s Kitchen in Daredevil. While the film was met with mixed reviews, it played an important role in highlighting the blind hero. In that same movie, Jennifer Garner played the lethal assassin initially fights Daredevil. Later, Garner starred in a spin-off as the character, but Elektra bombed becoming one of Marvel’s lowest earning movies of all time. Now, Garner is returning to the role for a cameo in Deadpool & Wolverine (via THR).

Pyro

Last Seen: X-Men: The Last Stand (2006)

Pyro was originally a member of the X-Men academy, where he learned to control his abilities under the tutelage of Professor X. However, his hot-headed nature led to the young man growing tired of hiding, and he joined the Brotherhood of Mutants under Magneto. Aaron Stanford played the character in X-Men 2, and X-Men: The Last Stand.

Deathstrike

Last Seen: X-Men 2 (2003)

Wolverine was not the only person to be experimented on by the secret Weapon X organization. In X-Men 2, Wolverine tracks down the people responsible for binding his skeleton with adamantium in a cruel experiment that almost killed him. However, upon arriving at the facility, he faced off against another recipient who stayed loyal to the program. Deathstrike was a formidable foe with similar adamantium enhancements, but she was ultimately killed by Wolverine. Her character in D&W is likely a variant from another reality, but both are played by Kelly Hu.

Azazel

Last Seen: X-Men: First Class (2011)

Azazel from Marvel Comics is the father of Nightcrawler, and a teleporting demon from another dimension. Thus far, the character has only had one appearance in a live-action film, in X-Men: First Class. Azazel was played by Jason Fleming in the 2011 film, and he will reprise the role in D&W. Between First Class and Days of Future Past, the character was killed off-screen, but with the multiverse being explored in D&W, Azazel is back.

Toad

Last Seen: X-Men (2000)

Toad is a mutant whose name reveals pretty much everything about their powers. His mutation allows him to move and engage in ways similar to a toad, utilizing his long stretchy tongue, and his extraordinary jumping skills. In the original X-Men movie, Toad was played by Ray Park, who also played Darth Maul in Star Wars: Episode I – The Phantom Menace just one year earlier. Now Park is set to return alongside many of the other former members of the Brotherhood in Deadpool & Wolverine.

Callisto

Last Seen: X-Men: The Last Stand (2006)

Callisto’s power makes her one of the most useful mutants, due to her ability to detect other mutants, and their power levels. Originally, she led a small group of mutants independently, before being recruited by Magneto in X-Men: The Last Stand. The character, as portrayed by Dania Ramirez, is returning in Deapool & Wolverine, and it appears her alignment has not shifted.

The Russian

Last Seen: The Punisher (2004)

The Russian is a villain that is frequently tied to characters like the Punisher, and in that vein, he was last seen played by Kevin Nash in the 2004 movie, The Punisher. However, there is a clear scene which showcases a character in the iconic red and white striped shirt which The Russian is famous for, and the actor Billy Clements posted on Instagram to confirm his character was in the trailer with a snapshot of the scene. It may be a different actor, but the presence of the threatening villain is still very exciting.

Alioth

Last Seen: Loki Season 1

Further tying in with the TVA and the crossing between the multiverse, the Deadpool & Wolverine trailer confirmed the presence of one terrifying threat that has appeared very recently in the MCU. In Loki season 1, when Loki makes it to the void at the end of time, he finds a number of variants of himself trapped there. However, it isn’t long before he encounters the terrifying monster made of smoke and lightning named Alioth. The creature being in the trailer confirms at least one location which will feature in D&W, which also explains the number of variants present.

Colossus

Last Seen: Deadpool 2 (2018)

Colossus may be a staple of the Deadpool trilogy, but he was also brought in as a cameo to connect the wider X-Men universe to Deadpool in 2016. The character was also present in both of the earlier X-Men trilogies, played by Daniel Cudmore until Stefan Kapicic took over the role for the Deadpool series, providing the voice for the now permanently transformed character. Kapicic will again reprise the role in Deadpool & Wolverine.

Negasonic Teenage Warhead

Last Seen: Deadpool 2 (2018)

Another mainstay of the Deadpool films, Negasonic Teenage Warhead, has appeared in both of the first entries and is now returning for Deadpool & Wolverine. However, since this third film takes the character to the MCU, it’s worth mentioning Negasonic as a cameo, who is now officially appearing in the MCU. Negasonic is one of the teenage mutants studying at Xavier’s School for Gifted Youngsters. She will be played by Brianna Hildebrand, who also portrayed the role in Deadpool and Deadpool 2.

Yukio

Last Seen: Deadpool 2 (2018)

Yukio has appeared in both The Wolverine, where she was played by Rila Fukushima, and in Deadpool 2, where she is played by Shioli Kutsuna. Depending on the timeline, her powers differ, with The Wolverine’s character having the ability to predict a person’s death, and the Deadpool 2 character controlling electricity. Thus far, only the version played by Kutsuna has been confirmed to appear in Deadpool & Wolverine, but it would be interesting to see the variants interact if Fukushima also returns.

Shatterstar

Last Seen: Deadpool 2 (2018)

Shatterstar has a brief role in Deadpool 2. When Deadpool recruits a group of superheros to be a part of the X-Force, Shatterstar is one of the successful new recruits. However, despite passing the interview, very little is seen of th character, as he, and almost all the other members of the team die before the mission gets into full swing. He is an alien from Mojoworld, and extremely arrogant. With Lewis Tan returning to reprise the role in Deadpool & Wolverine, hopefully the character will get more screentime, but that seems unlikely as Wade will not be keen to share the spotlight even more than he already is.

Dopinder

Last Seen: Deadpool 2 (2018)

Dopinder went from being a random taxi driver Deadpool hires in the 2016 movie, to being Deadpool’s personal taxi guy, and a fan-favorite character in the films. Dopinder is played by Karan Soni, and despite his lack of powers, he will be present in Deadpool & Wolverine as one of the standout characters from the trilogy. However, this will be his first time officially in the MCU.

Peter

Last Seen: Deadpool 2 (2018)

Peter is another random human with no mutant abilities or special powers. But he does have a can-do attitude. Peter manages to join Deadpool’s superhero team, the X-Force, and while the rest of the team plans to dive head first into danger, Peter sensibly warns of the high winds, which lead to the character’s accidental deaths. When Deadpool steals Cable’s time travel device, he goes back in time to warn Peter and saves his life, which provides the basis for the character returning in Deadpool & Wolverine, once again played by Rob Delaney.

Vanessa Carlysle

Last Seen: Deadpool 2 (2018)

In the comics, Vanessa is a mutant with the ability to shapeshift, but thus far in the Deadpool series, she appears to be a normal human woman. Prior to Wade’s diagnosis, and the experimental treatment that led to his scarring and immortality, Wade and Vanessa were engaged. Vanessa has since died and been resurrected by Wade, and is set to appear in Deadpool & Wolverine. Morena Baccarin will reprise the role.

Ant-Man (Skull)

Last Seen: Ant-Man and The Wasp: Quantumania (2023)

Paul Rudd’s Ant-Man, aka Scott Lang, has been a staple of the MCU since 2015s Ant-Man. Since becoming an Avenger, Scott has helped save the world, and he was instrumental in helping the Avenger’s learn about quantum space, which led to the heroes bringing everyone back from Thanos’ snap. While Ant-Man remains alive and well in the MCU, as he was last seen fighting and defeating a powerful version of Kang, the Deadpool & Wolverine variant hasn’t fared as well, as his skull appears to house several villains.

Rob McElhenney

Bonus Cameo

As a special bonus cameo, Ryan Reynold’s business partner and friend is set to make a guest appearance in Deadpool & Wolverine (via Games Radar). McElhenney and Reynolds own a European football team together in Wrexham, United Kingdom. McElhenney is a popular actor in his own right, with his most well-known role being in It’s Always Sunny in Philadelphia, where he plays Mac. His role in Deadpool & Wolverine is unknown.